HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053210Generated: October 30, 2026
3,5-Bis-trifluoromethylphenylboronic acid → 3-(3-{[5-(3,5-Bis-trifluoromethyl-phenyl)-furan-2-carbonyl]-amino}phenyl)-acrylic acid ethyl ester
https://huagongshe.com/reaction/2053210
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,5-Bis-trifluoromethylphenylboronic acid | HCID 156265 | — |
| Reactant | 3-{3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68494560 | — |
| Product | 3-(3-{[5-(3,5-Bis-trifluoromethyl-phenyl)-furan-2-carbonyl]-amino}phenyl)-acrylic acid ethyl ester | HCID 72348811 | — |
Reaction Steps
The furyl bromide (99)(70 mg, 0.19 mmol) was coupled to 3,5-bis-trifluoromethyl-phenylboronic acid (55 mg, 0.21 mmol) acid using Method E, except that the reaction was heated at 100° C. The crude product was purified by column chromatography eluting with a stepped gradient of 0-10% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326732B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-ed1818f76bf24b4e98a40da25257b5e0 |
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| Source note | uspto-grants-2008_02 |
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