HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 3-{3-[(4-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 3-[3-(5-Bromo-2-fluoro-benzoylamino)-phenyl]-acrylic acid ethyl ester | HCID 68497072 | — |
| Product | 3-{3-[(4-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68497288 | — |
Reaction Steps
The phenyl bromide (106)(100 mg, 0.25 mmol) was coupled to phenylboronic acid (34 mg,×0.28 mmol) using Method E. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326732B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-bf3ebd240ce3471dabdfbee03deb4707 |
| Source note | uspto-grants-2008_02 |