4-Fluorophenylboronic acid → 4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid

HRID 2053220Notes

Reaction equation

HRID 2053220 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[F:11][C:5]1[CH:4]=[CH:3][C:2]([C:16]2[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=2)=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 27363155-Bromo-2-fluorobenzoic acid

Product 1

HCID 463123334,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid

Procedure

5-Bromo-2-fluorobenzoic acid (250 mg, 1.14 mmol) was coupled to 4-fluoro-phenylboronic acid (192 mg, 1.37 mmol) using Method E to give the title compound. No chromatography was necessary.

Sources & evidence

ORD record
ord-df18dddda4b1472da13d6a0906ced9cb
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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