3-Aminocinnamic acid ethyl ester → 3-(3-[(4,4'-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl)-acrylic Acid Ethyl Ester

HRID 2053221Notes

Reaction equation

HRID 2053221 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:15]([OH:17])=O.[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:15]([C:3]2[CH:4]=[C:5]([C:8]3[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=3)[CH:6]=[CH:7][C:2]=2[F:1])=[O:17])[CH:25]=1)[CH3:19]

Participants

3

Reactant 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 463123334,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid

Product 1

HCID 684973963-(3-[(4,4'-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl)-acrylic Acid Ethyl Ester

Procedure

4,4′-Difluoro-biphenyl-3-carboxylic acid (100 mg, 0.43 mmol) was coupled to aniline (60)(82 mg, 0.43 mmol) using Method C to give the title compound.

Sources & evidence

ORD record
ord-5e79b046ec1c43dc806a2d562a2dec6f
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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