3-Fluorophenylboronic acid → HCID 59654732, compound

Participants

Reaction Steps

The furyl bromide (16)(100 mg, 0.30 mmol) was coupled to 3-fluoro-phenylboronic acid (42 mg, 0.30 mmol) using Method E. During this reaction, hydrolysis occurred. The residue was extracted using Work-up E1 to give the title compound. Yield: 26 mg, 25%; LC/MS tr 1.45 min; MS(ES+) m/z 339 (M+H); HPLC Purity: 91%; 1H NMR (400 MHz; DMSO): δ 3.50 (s, 2H), 6.95 (d, 1H), 7.15 (t, 1H), 7.20 (d, 1H), 7.24 (t, 1H), 7.32 (d, 1H), 7.46 (q, 1H), 7.56 (s, 1H), 7.62 (d, 1H), 7.74 (d, 1H), 7.83 (d, 1H), 10.13 (s, 1H)

Provenance & Evidence