HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminocinnamic acid ethyl ester → 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Reactant | 6-(4-Fluorophenyl)picolinic acid | HCID 21081708 | — |
| Product | 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68496911 | — |
Reaction Steps
Carboxylic acid (152)(50 mg, 0.23 mmol) was coupled to aniline (60)(44 mg, 0.23 mmol) using Method C. The crude residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326732B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-62187c91ddfa44c5b5564e5fc7545fdc |
| Source note | uspto-grants-2008_02 |