Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorophenylboronic acid → 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-propionic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| 반응물 | 3-(3-{[6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-propionic acid ethyl ester | HCID 59654822 | — |
| 생성물 | 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-propionic acid ethyl ester | HCID 59654830 | — |
반응 단계
The pyridyl bromide (161)(100 mg, 0.27 mmol) was coupled to 3-fluoro-phenylboronic acid (34 mg, 0.24 mmol) using Method E. The residue was purified by column chromatography eluting with 15% EtOAc in heptane to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07326732B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-1a64c45edf644d4880ac4b2b339f46d4 |
| 출처 메모 | uspto-grants-2008_02 |