5-Bromo-2-furanecarboxylic acid → HCID 39269710, compound

HRID 2053279Notes

Reaction equation

HRID 2053279 reaction equation
[Br:1][C:2]1[O:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[CH2:10]([O:12][C:13](=[O:23])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1)[CH3:11]>>[CH2:10]([O:12][C:13](=[O:23])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:7]([C:5]2[O:6][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:9])[CH:17]=1)[CH3:11]

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 412308Ethyl 2-(3-aminophenoxy)acetate

Product 1

HCID 39269710HCID 39269710, compound

Procedure

5-Bromo-furan-2-carboxylic acid (245 mg, 1.28 mmol) was coupled to aniline (64)(250 mg, 1.28 mmol) using Method C. The residue was purified by column chromatography eluting with 15% EtOAc in heptane to give the title compound.

Workup

  1. customThe residue was purified by column chromatography
  2. washeluting with 15% EtOAc in heptane

Sources & evidence

ORD record
ord-f70e6a9c3e764df3bfc09580b799d4c4
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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