6-Bromopyridine-2-carboxylic acid → HCID 72348814, compound

HRID 2053287Notes

Reaction equation

HRID 2053287 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]#[N:21])[CH:15]=[CH:16][CH:17]=1>>[C:20]([CH:19]=[CH:18][C:14]1[CH:13]=[C:12]([NH:11][C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[N:7]=2)=[O:10])[CH:17]=[CH:16][CH:15]=1)#[N:21]

Participants

3

Reactant 2

HCID 5939196-Bromopyridine-2-carboxylic acidHCID 534254963-(3-Amino-phenyl)-acrylonitrile

Product 1

HCID 72348814HCID 72348814, compound

Procedure

6-Bromo-pyridine-2-carboxylic acid (350 mg, 1.73 mmol) was coupled to aniline (88)(250 mg, 1.74 mmol) using Method C. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

Workup

  1. customThe residue was purified by column chromatography
  2. washeluting with 20% EtOAc in heptane

Sources & evidence

ORD record
ord-9b118f49ba394214bf42b8ec5ac2b9ff
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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