5-Bromo-2-fluorobenzoic acid → HCID 68499179, compound

HRID 2053288Notes

Reaction equation

HRID 2053288 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]#[N:22])[CH:16]=[CH:17][CH:18]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH:19]=[CH:20][C:21]#[N:22])[CH:14]=1)=[O:9]

Participants

3

Reactant 2

HCID 27363155-Bromo-2-fluorobenzoic acidHCID 534254963-(3-Amino-phenyl)-acrylonitrile

Product 1

HCID 68499179HCID 68499179, compound

Procedure

5-Bromo-2-fluoro-benzoic acid (380 mg, 1.74 mmol) was coupled to aniline (88)(250 mg, 1.74 mmol) using Method C. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

Workup

  1. customThe residue was purified by column chromatography
  2. washeluting with 20% EtOAc in heptane

Sources & evidence

ORD record
ord-e4dde69e4b254accaf221ec1a9e51baf
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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