反应详情

The suspension of 6-quinolinecarboxaldehyde (6 g, 38 mmol), rhodanine (2-thioxo-4-thiazolidinone) (5.08 g, 38 mmol) and sodium acetate (12.5 g, 152 mmol) in acetic acid (50 mL) was stirred under reflux for 12 h. After cooling to room temperature, water (150 mL) was added. The solid was collected by filtration, washed with water and dried to obtain 5-[1-quinolin-6-yl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (10.2 g, 98%) as a yellow solid. LC-MS m/e 273 (MH+).

1. temperatureunder reflux for 12 h
2. filtrationThe solid was collected by filtration
3. washwashed with water
4. customdried