HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178518143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,2-Difluoro-2-pyridin-2-ylethaneamine | HCID 9964167 | — |
| Reactant | (5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one | HCID 58585737 | — |
| Product | HCID 178518143 | HCID 178518143 | — |
Reaction Steps
Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 2,2-difluoro-2-pyridin-2-yl-ethylamine (example 59d) and DIEA to give 2-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. The product was dissolved in methanol (5 mL). 2 M HCl in ether (2 mL) was added. After adding ether, the solid was collected by filtration, washed with ether and dried to give 2-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one hydrochloride. LC-MS m/e 397 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326786B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2b904d29cfaf42a1b44c5a0617ab25d8 |
| Source note | uspto-grants-2008_02 |