4-Aminobenzenesulfonyl fluoride → HCID 9914905, compound

HRID 2053367Notes

Reaction equation

HRID 2053367 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[CH:17][C:13]=2[C:14](Cl)=[O:15])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([F:35])(=[O:34])=[O:33])=[CH:28][CH:27]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[CH:17][C:13]=2[C:14]([NH:25][C:26]2[CH:31]=[CH:30][C:29]([S:32]([F:35])(=[O:34])=[O:33])=[CH:28][CH:27]=2)=[O:15])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 668234-Aminobenzenesulfonyl fluorideHCID 98433672-(4-Chloro-phenylsulfonylamino)4,5-dimethoxy-benzoyl chloride

Product 1

HCID 9914905HCID 9914905, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

10.00 g (25.6 mmol) of 2-(4-Chloro-phenylsulfonylamino)4,5-dimethoxy-benzoyl chloride were mixed with 300 ml of toluene, 4.49 g (25.6 mmol) of 4-aminobenzenesulfonyl fluoride were added and the mixture was heated under reflux for 4 h. After cooling the precipitated solid was filtered off with suction and washed with toluene. 11.71 g (87%) of the title compound having a melting point of 216-219° C. were obtained.

Workup

  1. additionwere added
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 4 h
  4. temperatureAfter cooling the precipitated solid
  5. filtrationwas filtered off with suction
  6. washwashed with toluene
  7. customwere obtained

Sources & evidence

ORD record
ord-85d53de08b754b3a9c600f4db450242a
Source dataset
uspto-grants-2008_02
Patent number
US07326789B2

Reaction notes

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