Hydroxylamine → HCID 135436619, compound

Participants

Reaction Steps

To a solution of 5-(6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinolin-3-yl)-isoxazole-3-carboxaldehyde in MeOH (20 mL), aq. NH2OH (1 mmol) was added. The resulting mixture was stirred at RT for 2 hr. The reaction mixture was concentrated and water (20 mL) was added. The precipitate formed was then collected by suction filtration and dried in vacuo. Above oxime (365 mg, 1 mmol) was dissolved in pyridine (10 mL) and acetic anhydride (0.3 mL, 2 mmol) was added. The resulting mixture was stirred overnight and concentrated. The residue obtained was purified with (30% EtOAc:Hexane) to obtain the title compound. Yield 67%.

Provenance & Evidence