Sodium Hydroxide → HCID 10007814, compound

HRID 2053487Notes

Reaction equation

HRID 2053487 reaction equation
[CH3:1][C:2]1([CH3:37])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=3)[CH:5]=[C:4]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[C:31]([F:36])[CH:30]=3)[C:3]1=2.[OH-].[Na+]>>[F:36][C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][C:32]=1[F:35])[CH2:28][O:27][C:4]1[C:3]2[C:2]([CH3:1])([CH3:37])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]=2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]2[CH:18]=[CH:19][C:20]([C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86599531HCID 86599531, compound

Product 1

HCID 10007814HCID 10007814, compound

Procedure

In a manner similar to that of Example 1g, by reacting 680 mg (1.2 mmol) of methyl 4-[5,5,8,8-tetramethyl-4-(3,4-difluorobenzyloxy)-5,6,7,8-tetrahydro-2-naphthylselanylethynyl]benzoate with 240 mg of sodium hydroxide. A yellow crystallized solid is obtained (m=402 mg; yield=61%; m.p.=218° C.).

Workup

  1. customA yellow crystallized solid
  2. customis obtained (m=402 mg; yield=61%; m.p.=218° C.)

Sources & evidence

ORD record
ord-e4809040d05d4318aaddd4449ccce669
Source dataset
uspto-grants-2008_02
Patent number
US07326803B2

Reaction notes

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