Sodium Hydroxide → HCID 9959316, compound

HRID 2053488Notes

Reaction equation

HRID 2053488 reaction equation
[CH3:1][C:2]1([CH3:37])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=3)[CH:5]=[C:4]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][C:30]=3[F:36])[C:3]1=2.[OH-].[Na+]>>[F:36][C:30]1[CH:31]=[C:32]([F:35])[CH:33]=[CH:34][C:29]=1[CH2:28][O:27][C:4]1[C:3]2[C:2]([CH3:1])([CH3:37])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]=2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]2[CH:18]=[CH:19][C:20]([C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86599534HCID 86599534, compound

Product 1

HCID 9959316HCID 9959316, compound

Procedure

In a manner similar to that of Example 1g, by reacting 790 mg (1.4 mmol) of methyl 4-[5,5,8,8-tetramethyl-4-(2,4-difluorobenzyloxy)-5,6,7,8-tetrahydro-2-naphthylselanylethynyl]benzoate with 240 mg of sodium hydroxide. A yellow crystallized solid is obtained (m=502 mg; yield=65%; m.p.=219° C.).

Workup

  1. customA yellow crystallized solid
  2. customis obtained (m=502 mg; yield=65%; m.p.=219° C.)

Sources & evidence

ORD record
ord-13d35c4331e348179047be915cd78145
Source dataset
uspto-grants-2008_02
Patent number
US07326803B2

Reaction notes

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