Sodium Hydroxide → HCID 12084850, compound

HRID 2053491Notes

Reaction equation

HRID 2053491 reaction equation
[CH3:1][C:2]1([CH3:36])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=3)[CH:5]=[C:4]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][CH:30]=3)[C:3]1=2.[OH-].[Na+]>>[Br:35][C:32]1[CH:31]=[CH:30][C:29]([CH2:28][O:27][C:4]2[C:3]3[C:2]([CH3:1])([CH3:36])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]=3[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=3)[CH:5]=2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 87752936HCID 87752936, compound

Product 1

HCID 12084850HCID 12084850, compound

Procedure

In a manner similar to that of Example 1g, by reacting 320 mg (0.5 mmol) of methyl 4-[5,5,8,8-tetramethyl-4-(4-bromobenzyloxy)-5,6,7,8-tetrahydro-2-naphthylselanylethynyl]benzoate with 110 mg of sodium hydroxide. A white crystallized solid is obtained (m=240 mg; yield=66%; m.p.=265° C.).

Workup

  1. customA white crystallized solid
  2. customis obtained (m=240 mg; yield=66%; m.p.=265° C.)

Sources & evidence

ORD record
ord-f7bfcef8234d440a92841d376997b5b3
Source dataset
uspto-grants-2008_02
Patent number
US07326803B2

Reaction notes

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