4-Iodobenzoic acid → HCID 69292484, compound

Participants

Reaction Steps

In a manner similar to that of Example 1g, by reacting 580 mg (1.6 mmol) of 1-[4-(4-fluorobenzyloxy)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl]prop-2-yn-1-ol with 330 mg (1.3 mmol) of 4-iodobenzoic acid in the presence of 12 mg of copper iodide and 23 mg of bis(triphenylphosphine)dichloropalladium. The desired product is obtained in the form of beige-colored crystals (m=420 mg; yield=67%; m.p. 188° C.).

Provenance & Evidence