HRID2053497

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)c1ccc2cc(C(=O)c3cc(OCc4ccc(F)cc4)c4c(c3)C(C)(C)CCC4(C)C)ccc2c1

HCID69292514

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CCC(C)(C)c2c(OCc3ccc(F)cc3)cc(C(=O)c3ccc4cc(C(=O)O)ccc4c3)cc21

HCID10346250

未命名化合物

PROCEDURE

实验过程

In a manner similar to that of Example 1g, by reacting 250 mg (0.5 mmol) of methyl 6-{1-[4-(4-fluorobenzyloxy)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl]methanoyl}-2-naphthalenecarboxylate with 40 mg of sodium hydroxide. A white crystallized solid is obtained (m=235 mg; yield=66%; m.p.=277° C.).

WORKUP

后处理

customA white crystallized solid
customis obtained (m=235 mg; yield=66%; m.p.=277° C.)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-68b3f2a12d804976bd23980f0481f96b
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07326803B2
来源说明: uspto-grants-2008_02

反应 SMILES

[F:1][C:2]1[CH:39]=[CH:38][C:5]([CH2:6][O:7][C:8]2[C:17]3[C:16]([CH3:19])([CH3:18])[CH2:15][CH2:14][C:13]([CH3:21])([CH3:20])[C:12]=3[CH:11]=[C:10]([C:22]([C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[CH:30]=[C:29]([C:34]([O:36]C)=[O:35])[CH:28]=[CH:27]4)=[O:23])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:39]=[CH:38][C:5]([CH2:6][O:7][C:8]2[C:17]3[C:16]([CH3:19])([CH3:18])[CH2:15][CH2:14][C:13]([CH3:20])([CH3:21])[C:12]=3[CH:11]=[C:10]([C:22]([C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[CH:30]=[C:29]([C:34]([OH:36])=[O:35])[CH:28]=[CH:27]4)=[O:23])[CH:9]=2)=[CH:4][CH:3]=1