Sodium Hydroxide → HCID 10346250, compound

HRID 2053497Notes

Reaction equation

HRID 2053497 reaction equation
[F:1][C:2]1[CH:39]=[CH:38][C:5]([CH2:6][O:7][C:8]2[C:17]3[C:16]([CH3:19])([CH3:18])[CH2:15][CH2:14][C:13]([CH3:21])([CH3:20])[C:12]=3[CH:11]=[C:10]([C:22]([C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[CH:30]=[C:29]([C:34]([O:36]C)=[O:35])[CH:28]=[CH:27]4)=[O:23])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:39]=[CH:38][C:5]([CH2:6][O:7][C:8]2[C:17]3[C:16]([CH3:19])([CH3:18])[CH2:15][CH2:14][C:13]([CH3:20])([CH3:21])[C:12]=3[CH:11]=[C:10]([C:22]([C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[CH:30]=[C:29]([C:34]([OH:36])=[O:35])[CH:28]=[CH:27]4)=[O:23])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69292514HCID 69292514, compound

Product 1

HCID 10346250HCID 10346250, compound

Procedure

In a manner similar to that of Example 1g, by reacting 250 mg (0.5 mmol) of methyl 6-{1-[4-(4-fluorobenzyloxy)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl]methanoyl}-2-naphthalenecarboxylate with 40 mg of sodium hydroxide. A white crystallized solid is obtained (m=235 mg; yield=66%; m.p.=277° C.).

Workup

  1. customA white crystallized solid
  2. customis obtained (m=235 mg; yield=66%; m.p.=277° C.)

Sources & evidence

ORD record
ord-68b3f2a12d804976bd23980f0481f96b
Source dataset
uspto-grants-2008_02
Patent number
US07326803B2

Reaction notes

Loading…