反应详情

A mixture of cis-4,5-bis-(3-chlorophenyl)imidazolidine-2-thione (33) (8.23 g, 0.0254 mol) and methyl iodide (3.17 mL, 0.0509 mol) in abs. EtOH (25 mL) is heated at 90° C. for 8 h. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue triturated with abs EtOH. The insoluble material is filtered to give 10.1 g of the product 50.

1. concentrationconcentrated in vacuo
2. customthe residue triturated with abs EtOH
3. filtrationThe insoluble material is filtered