Methyl iodide → HCID 68569925, compound

HRID 2053514Notes

Reaction equation

HRID 2053514 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[NH:11][C:10](=[S:20])[NH:9]2)=[CH:4][CH:3]=1.[CH3:21][I:22]>CCO>[IH:22].[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C@H:12]2[C@@H:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[NH:9][C:10]([S:20][CH3:21])=[N:11]2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 54361828cis-4,5-bis-(4-Chlorophenyl)imidazolidine-2-thione

Product 1

HCID 68569925HCID 68569925, compoundYield 75.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of cis-4,5-bis-(4-chlorophenyl)imidazolidine-2-thione (34) (30 g, 0.0928 mol) and methyl iodide (11.5 mL, 0.186 mol) in abs. EtOH (100 mL) is heated at 90° C. for 8 h. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue triturated with abs EtOH. The insoluble material is filtered to give 32.5 g of the product 51.

Workup

  1. concentrationconcentrated in vacuo
  2. customthe residue triturated with abs EtOH
  3. filtrationThe insoluble material is filtered

Sources & evidence

ORD record
ord-215a311ab64e4feca952e9ab3ba4659e
Source dataset
uspto-grants-2008_02
Patent number
US07326792B2

Reaction notes

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