HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053537Generated: October 30, 2026
Benzylamine → tert-butyl (4S,5R)-2-(benzylamino)-4,5-bis(4-fluorophenyl)-4,5-dihydroimidazole-1-carboxylate
https://huagongshe.com/reaction/2053537
Participants
| Role | Name | HCID | Charge |
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| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 4-Fluorophenyl-2-methylthio-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester | HCID 86596323 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-butyl (4S,5R)-2-(benzylamino)-4,5-bis(4-fluorophenyl)-4,5-dihydroimidazole-1-carboxylate | HCID 68570645 | 123.2% |
Reaction Steps
A mixture of intermediate 62 (0.5 g, 1.24 mmol), benzylamine (0.680 mL, 6.2 mmol) and MeOH (0.1 mL) is heated at 100° C. overnight. The reaction mixture is cooled to RT and purified by chromatography on silica gel; gradient elution with heptane:EtOAc (75:25-60:40) gives 0.354 g of the product 160. 1H NMR (CDCl3) δ 7.55-7.25 (m, 6H), 6.95-6.85 (m, 2H), 6.80-6.60 (m, 6H), 5.45-5.20 (m, 2H), 4.75-4.55 (m, 2H), 1.16 (s, 9H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326792B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-250e502e6348426e9c79db3af48933db |
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| Source note | uspto-grants-2008_02 |
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