HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4S,5R)-N-benzyl-4,5-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (4S,5R)-2-(benzylamino)-4,5-bis(4-fluorophenyl)-4,5-dihydroimidazole-1-carboxylate | HCID 68570645 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (4S,5R)-N-benzyl-4,5-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride | HCID 68570275 | — |
Reaction Steps
Hydrogen chloride is bubbled into a solution of 160 (350 mg, 0.76 mmol) in EtOAc (20 mL) for 0.5 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue is triturated with Et2O to give 230 mg of the product 161. 1H NMR (DMSO-d6) δ 9.50-8.40 (m, 3H), 7.55-7.250 (m, 5H), 7.05-6.85 (m, 8H), 5.48 (s, 2H), 4.55 (d, 2H); MS: m/z 364 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326792B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-747d9b0630a04376815f26c9a8d8488c |
| Source note | uspto-grants-2008_02 |