Acetyl chloride → Ethyl 3-(3,4-difluorophenyl)propanoate

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Reaction Steps

To a solution of 3-(3,4-difluorophenyl)propionic acid (1.0 g, 5.4 mmol) in EtOH (10 mL) is added dropwise acetyl chloride (1.0 mL, 14.1 mmol), and the solution is stirred at RT for 2 h. The solvent is rotary evaporated, and the residue purified by chromatography on silica gel; elution with heptane:EtOAc (4:1) gives 0.99 g of the product 249. 1H NMR (CDCl3) δ 7.10-6.85 (m, 3H), 4.13 (q, 2H), 2.90 (t, 2H), 3.35-2.59 (t, 2H), 1.23 (t, 2H); MS: m/z 215 (M++1).

Provenance & Evidence