HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053589Generated: October 30, 2026
Trifluoroacetic acid → HCID 59655349, compound
https://huagongshe.com/reaction/2053589
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-[2-(4-Fluorophenyl)-2-oxoethyl]-cis-4,5-diphenyl-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester | HCID 86596337 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59655349 | HCID 59655349 | 47.4% |
Reaction Steps
To a cold (0° C.) solution of 257 (458 mg, 1.0 mmol) in dichloromethane (25 mL) is added TFA (1.5 mL). The reaction mixture is stirred for 20 min. at 0° C., and at RT for 30 min. The solution is poured into cold sat. sodium bicarbonate solution, and the mixture extracted with EtOAc. The organic layer is separated, dried (MgSO4), and filtered. The filtrate is rotary evaporated, and the residue is recrystallized from Et2O to give 170 mg of the product 258. 1H NMR (CDCl3) δ 10.60-8.80 (bs, 1H), 8.00-7.80 (m, 2H), 7.20-7.00 (m, 9H), 7.00-6.85 (m, 4H), 5.50 (bs, 1H), 5.30 (s, 2H); MS: m/z 359 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326792B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-c4f0367189994cd6a98bbba40f973abe |
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| Source note | uspto-grants-2008_02 |
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