5-chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid → [5-Chloro-3-methyl-2-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone
Reaction equation
[Cl:1][c:2]1[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH:27]([CH2:31][O:32][C:33](=[O:34])[c:35]4[cH:36][cH:37][cH:38][cH:39][cH:40]4)[CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]2)[n:6]1.[Cl:41][c:42]1[n:43][c:44](-[c:45]2[cH:46][cH:47][cH:48][c:49]([C:50]([F:51])([F:52])[F:53])[cH:54]2)[n:55]([CH3:56])[c:57]1[C:58]([OH:59])=[O:60].[NH:61]1[CH2:62][CH2:63][CH:64]([N:65]2[CH2:66][CH2:67][CH2:68][CH:69]2[CH2:70][O:71][C:72](=[O:73])[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[CH2:80][CH2:81]1>>[Cl:1][c:2]1[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH:27]([CH2:31][OH:32])[CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]2)[n:6]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-7656b265367f4f9ba343256d74563146
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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