Methyl (2S)-methoxy(phenyl)ethanoate → 2-(Methoxy-phenyl-methyl)-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole Trifluoroacetate

Participants

Reaction Steps

Employing the general trimethylaluminum coupling procedure and using methoxy-(S)-phenyl-acetic acid methyl ester prepared in accordance with Step 1 as described above and meso-1,2-diphenylethylene-diamine there was made, 2-(Methoxy-phenyl-methyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole trifluoroacetate. 1H NMR (DMSO) δ 11.11 (bs, 1H), 7.7-7.5 (m, 5H), 7.1-7.0 (m, 6H), 6.90-6.85 (m, 2H), 6.8-6.7 (m, 2H), 5.81 (s, 2H), 5.65 (s, 1H), 3.49 (s, 3H); LC/MS: 3.69 min/m/z 343 (M++1)

Provenance & Evidence