HCID 22042580, compound → HCID 22042577, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.2 g of N-methyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide in 10 mL of THF were added 0.7 mL of a 1 M solution 4-chlorophenyl magnesium bromide at −78° C. The resulting mixture was stirred at −78° C. for 4 hr. After this time, the reaction mixture was quenched by the addition of a saturated aqueous solution of ammonium chloride and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered and the filtrate was concentrated. The residue was purified by chromatography on silica gel (hexanes:EtOAc, 7:1) to give the title compound. 1H-NMR (CDCl3) δ 2.96 (br s, 1 H), 3.17 (s, 3 H), 7.10-7.59 (m, 13 H). Mass Spectrum (CI+) m/e=456 (M+1).

Provenance & Evidence