4-Methyl-1-pentyne → HCID 22042637, compound

HRID 2053669Notes

Reaction equation

HRID 2053669 reaction equation
[CH3:1][N:2]([C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:23])[C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=1)[S:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:5])=[O:4].[CH3:24][CH:25]([CH3:29])[CH2:26][C:27]#[CH:28]>>[OH:23][C:18]([C:15]1[CH:16]=[CH:17][C:12]([N:2]([CH3:1])[S:3]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)(=[O:5])=[O:4])=[CH:13][CH:14]=1)([C:19]([F:21])([F:22])[F:20])[C:28]#[C:27][CH2:26][CH:25]([CH3:29])[CH3:24]

Participants

3

Reactant 2

HCID 1389484-Methyl-1-pentyneHCID 22042580HCID 22042580, compound

Product 1

HCID 22042637HCID 22042637, compound

Procedure

The compound was prepared from N-methyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide (Example 22, Step A) and 4-methyl-pent-1-yne following the procedure described in Example 29. 1H NMR (CDCl3) δ 1.01 (d, J=6.6 Hz, 6 H), 1.90 (sept, J=6.6 Hz, 1 H), 2.21 (d, J=7.7 Hz, 2 H), 3.17 (s, 3 H), 3.24 (br s, 1 H), 7.12-7.68 (m, 9 H). Mass Spectrum (CI+) m/e=426 (M+1).

Sources & evidence

ORD record
ord-dcf900546f734896b422bf7556a5be39
Source dataset
uspto-grants-2008_02
Patent number
US07326812B2

Reaction notes

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