HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-Fluorobiphenyl-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Fluoro-4-phenylbenzoic acid | HCID 11390290 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluorobiphenyl-4-carbonyl chloride | HCID 46314877 | — |
Reaction Steps
Combine 3-fluorobiphenyl-4-carboxylic acid 10.46 g (0.048 mol), 432 mL of methylene chloride, 7 drops of dimethylformamide, and 5.44 mL (0.062 mol, 1.3 equiv) of oxalyl chloride. After 2 h, evaporate the solvent to afford 3-fluorobiphenyl-4-carbonyl chloride as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326731B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-5966ef2d4c4d4cf8b1c98dcdf3a9675a |
| Source note | uspto-grants-2008_02 |