Lawesson's reagent → HCID 60088435, compound

Participants

Reaction Conditions

Reaction Steps

Step c) Add Lawesson reagent (1.8 g, 3.6 mmol) to N-(4-fluorobenzyl)acetamide (0.9 g, 5.4 mmol) in 50 mL of toluene and heat to 80° C. for 12 hours. Remove solvent under reduced pressure. Purify the residue by column chromatography (silica gel, Acetone: Hexane=20:80) to give a mixture. Wash with ether and discard insoluble solid impurities by filtration. Remove solvent under reduced pressure to give N-(4-fluorobenzyl)-thioacetamide (0.7 gm) in 71% as a yellow solid: MS 184 (MH+).

Provenance & Evidence