2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 69318785, compound

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Reaction Steps

10-(5-Chloro-4-cyclohex-1-en-1-yl-2-methoxybenzoyl)-N-[3-(dimethylamino) propyl]-N-methyl-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine-3-carboxamide of Example 2 (0.100 g, 0.174 mmol) was dissolved in diethyl ether (5 mL). To the ether solution was added a solution of citric acid monohydrate (0.037 g, 0.174 mmol) in hot diethyl ether (5 mL), resulting in formation of a white precipitate. The precipitate was filtered and rinsed thoroughly with hot diethyl ether and dried in vacuo to afford the title compound (0.137 g) as a white powder, m.p 107-138° C.

Provenance & Evidence