10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine → HCID 10199923, compound

HRID 2053747Notes

Reaction equation

HRID 2053747 reaction equation
[CH3:1][C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[NH:23][CH2:22][C:21]=12>>[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[N:23]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([C:3]4[CH2:4][CH2:5][CH2:6][CH2:7][C:2]=4[CH3:1])=[CH:16][CH:15]=3)=[O:14])[CH2:22][C:21]=12

Participants

3

Reactant 2

HCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepineHCID 22219711HCID 22219711, compound

Product 1

HCID 10199923HCID 10199923, compoundYield 91.9%

Procedure

4-(2-Methyl-cyclohex-1-en-1-yl)-benzoic acid of Step C (0.720 g, 3.33 mmol) and 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine (0.674 g, 3.66 mmol) were reacted according to the procedure of Example 1, Step D. The title compound was purified by recrystallization from petroleum ether to afford white crystals (1.17 g), m.p. 119-120° C.

Workup

  1. customThe title compound was purified by recrystallization from petroleum ether

Sources & evidence

ORD record
ord-c4caf10035fa4482b8fc9d9bc7e897c5
Source dataset
uspto-grants-2008_02
Patent number
US07326700B2

Reaction notes

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