HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178436689, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(5-chloro-1H-1,3-benzodiazol-2-yl)ethan-1-amine | HCID 24252558 | — |
| Reactant | 3-Ethynyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 85977055 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178436689 | HCID 178436689 | 46% |
Reaction Steps
Prepared analogously to Example 1g from 3-ethynyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and rac.-1-(5-chlorobenzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 46%; Rf value: 0.48 (silica gel; dichloromethane/ethanol=9:1); C23H21ClN4O2 (420.90); mass spectrum: (M+H)+=421/423 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-8a490964d15a485684e905ddf9b6f8d8 |
| Source note | uspto-grants-2008_02 |