HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178474223, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(5-chloro-1H-1,3-benzodiazol-2-yl)ethan-1-amine | HCID 24252558 | — |
| Reactant | 3-methyl-4-(N-cyclobutyl-N-acetylamino)benzoic acid | HCID 69315360 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178474223 | HCID 178474223 | — |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(N-cyclobutyl-N-acetylamino)benzoic acid, TBTU, diisopropylethylamine, and 1-(5-chlorobenzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: quantitative; Rf value: 0.50 (silica gel; methylene chloride/ethanol=9:1); C23H25ClN4O2 (424.93); mass spectrum: (M+H)+=425/427 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2b895167d1584ff3937cacf2f5cab69c |
| Source note | uspto-grants-2008_02 |