Trifluoroacetic acid → HCID 178511777, compound

Participants

Reaction Steps

1.88 g (5.04 mmol) of (S)—N-tert-butoxycarbonyl-1-(5-chloro-1H-benzimidazol-2-yl)-2-(pyridin-4-yl)ethylamine is dissolved in 35 mL of dichloromethane and combined with 5 mL of trifluoroacetic acid. The mixture is stirred for 16 hours at ambient temperature and then the volatile constituents are distilled off. The residue is made alkaline with 2 molar sodium hydroxide solution, evaporated down and then digested with a little water and ethyl acetate. The crystals thus obtained are dried. Yield: 1.38 g (quantitative); Rf value: 0.09 (silica gel; dichloromethane/methanol=9:1); C14H13ClN4 (272.74); mass spectrum: (M+H)+=273/275 (chlorine isotope).

Provenance & Evidence