Diisopropylethylamine → HCID 178516784, compound

Participants

Reaction Steps

0.182 g (0.50 mmol) of 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-hydroxy-carbonylbenzamide is dissolved in 5 mL of N,N-dimethylformamide and 160.5 mg (0.50 mmol) of TBTU and 85.6 μL (0.50 mmol) of diisopropylethylamine are added successively with stirring at ambient temperature. Then a solution of 50 mg (0.50 mmol) of 2-oxopiperazine in 5 mL of N,N-dimethylformamide is added dropwise and the reaction mixture is stirred for 3 hours at ambient temperature. Then the solvent is eliminated in vacuo and the residue purified by chromatography on silica gel (gradient: dichloromethane/methanol=100:0 □93:7). Yield: 99 mg (44%); C20H17C12N5O3 (446.30); mass spectrum: (M+H)+=446/448/450 (chlorine isotope).

Provenance & Evidence