HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178523079, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-(2,3-Dihydroimidazo[2,1-b]thiazol-5-yl)benzoic acid | HCID 69309859 | — |
| Reactant | HCID 178510549 | HCID 178510549 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178523079 | HCID 178523079 | 73% |
Reaction Steps
Prepared analogously to Example 1g from 4-(2,3-dihydroimidazo[2,1-b]thiazol-5-yl)benzoic acid, TBTU, triethylamine and (5-chloro-1H-benzimidazol-2-yl)methylamine in N,N-dimethylformamide. Yield: 73%; Rf value: 0.50 (silica gel; ethyl acetate/ethanol=9:1); C20H16ClN5OS (409.90); mass spectrum: (M+H)+=410/412 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-415e0b40591f4ba5a930b36cca3123ac |
| Source note | uspto-grants-2008_02 |