HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178428633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | HCID 178525236 | HCID 178525236 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178428633 | HCID 178428633 | — |
Reaction Steps
Prepared analogously to Example 1g from (5-chloro-1H-benzimidazol-2-yl)acetic acid, TBTU, N-methylmorpholine, and 4-amino-2-methylbenzoic acid pyrrolidine amide in N,N-dimethylformamide and subsequent chromatography on silica gel (gradient: dichloromethane/ethanol=100:0□25:1□19:1□19:1); Yield: 14 mg (7.1%); Rf value: 0.45 (silica gel; dichloromethane/ethanol=9:1); C21H21ClN4O2 (396.88); mass spectrum: (M−H)-=395/397 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-12b46fb259ed435eb930a509f1a859b3 |
| Source note | uspto-grants-2008_02 |