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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053783Generated: October 30, 2026

Diisopropylethylamine → HCID 178427045, compound

https://huagongshe.com/reaction/2053783

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acidHCID 12068686—
ReactantHCID 178463383HCID 178463383—
SolventDimethylformamideHCID 6228—
SolventEthanol ethylacetateHCID 21584252—
ProductHCID 178427045HCID 178427045—

Reaction Steps

Prepared analogously to Example 10d from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and rac.-1-(5-trifluoromethyl-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 90 mg (47% of theory); Rf value: 0.38 (silica gel; ethyl acetate/ethanol=9:1); C23H23F4N3O2 (444.46); mass spectrum: (M+H)+=445

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07326791B2
Source datasetuspto-grants-2008_02
ORD IDord-effd4388fe8d4386b0cf848648756895
Source noteuspto-grants-2008_02