HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427190, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178513919 | HCID 178513919 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178427190 | HCID 178427190 | — |
Reaction Steps
Prepared analogously to Example 10d from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (S)-3-amino-3-(5-chloro-1H-benzimidazol-2-yl)propionic acid amide in dimethylformamide. Yield: 97 mg (43% of theory); Rf value: 0.37 (silica gel; dichloromethane/methanol=9:1); C23H24ClN5O3 (453.93); mass spectrum: (M+H)+=454/456 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1d2a19c246dc4166ac86f54fe6e2ddac |
| Source note | uspto-grants-2008_02 |