HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-(2-methylpyrrolidin-1-ylcarbonyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methylpyrrolidine | HCID 13003 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178523088 | HCID 178523088 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-(2-methylpyrrolidin-1-ylcarbonyl)benzamide | HCID 178426208 | — |
Reaction Steps
Prepared analogously to Example 1d from 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-carboxybenzamide, 2-methylpyrrolidine, TBTU, and triethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 3.62 minutes; C21H20Cl2N4O2 (431.32); mass spectrum: (M+H)+=431.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-adc23b08523e4560ab7dbe14e974fb93 |
| Source note | uspto-grants-2008_02 |