HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178507739, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Reactant | HCID 178523088 | HCID 178523088 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178507739 | HCID 178507739 | — |
Reaction Steps
Prepared analogously to Example 1d from 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-carboxybenzamide, tert-butyl piperidin-3-ylcarbamate, TBTU, and triethylamine in DMSO at ambient temperature followed by Boc cleaving with trifluoroacetic acid analogously to Example 17. HPLC-MS results: retention time: 2.91 minutes; C21H21Cl2N5O2 (446,34); mass spectrum: (M+H)+=446.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-4f0153850ed5401ea7ea2c511bc67c35 |
| Source note | uspto-grants-2008_02 |