HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178427015, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178510547 | HCID 178510547 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427015 | HCID 178427015 | — |
Reaction Steps
Prepared analogously to Example 1g from C-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)methylamine, TBTU, diisopropylethylamine, and 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid in tetrahydrofuran. Yield: 190 mg (76%); Rf value: 0.67 (silica gel; dichloromethane/ethanol=8:2+2% ammonia solution); C20H20BrN5O2 (442,32); mass spectrum: (M+H)+=442/444 (bromine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-3a185bdfd7ef48c1aa305769ae712b11 |
| Source note | uspto-grants-2008_02 |