HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → Rac.-n-[1-(5-chloro-1h-benzimidazol-2-yl)]ethyl-3-trifluoromethyl-4-(pyrrolidin-1-ylcarbonyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 69311101 | HCID 69311101 | — |
| Reactant | HCID 178463384 | HCID 178463384 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | Rac.-n-[1-(5-chloro-1h-benzimidazol-2-yl)]ethyl-3-trifluoromethyl-4-(pyrrolidin-1-ylcarbonyl)benzamide | HCID 178464782 | — |
Reaction Steps
Prepared analogously to Example 1g from 3-trifluoromethyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and rac.-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: quantitative; Rf value: 0.50 (silica gel; methylene chloride/ethanol=9:1); C22H20ClF3N4O2 (464.88); mass spectrum: (M−H)-=463/465 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0e927819867a42c1946d83d990f9947b |
| Source note | uspto-grants-2008_02 |