HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178509976, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178453069 | HCID 178453069 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178509976 | HCID 178509976 | 59% |
Reaction Steps
Prepared analogously to Example 17 from 4-[2-(N-tert-butoxycarbonylaminomethyl)pyrrolidine-1-carbonyl]-N-[2-aminocarbonyl-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-chlorobenzamide and trifluoroacetic acid. Yield: 59% (mixture of all four stereoisomers); Rf value: 0.23 (silica gel; dichloromethane/methanol=7:3); C23H24Cl2N6O3 (503.39); mass spectrum: (M+H)+=503/505/507 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-c984bf4a132545cc915e7ee734ca9b7c |
| Source note | uspto-grants-2008_02 |