HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178509975, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178453068 | HCID 178453068 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178509975 | HCID 178509975 | 98% |
Reaction Steps
Prepared analogously to Example 17 from 4-[2-(N-tert-butoxycarbonylaminomethyl)pyrrolidin-1-ylcarbonyl]-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)-2-(1H-imidazol-4-yl)ethyl]benzamide and trifluoroacetic acid. Yield: 98% of theory; Rf value: 0.47 (silica gel; dichloromethane/methanol=7:3); C25H25C12N7O2 (526.43); mass spectrum: (M+H)+=526/528/530 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-36bb32107da14aefa2541b4b393efba3 |
| Source note | uspto-grants-2008_02 |