HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178509974, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | HCID 178453067 | HCID 178453067 | — |
| Product | HCID 178509974 | HCID 178509974 | — |
Reaction Steps
Prepared analogously to Example 17 from 4-[2-(N-tert-butoxycarbonylaminomethyl)pyrrolidin-1-ylcarbonyl]-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)-2-(pyridin-2-yl)ethyl]benzamide and trifluoroacetic acid. Yield: 216 mg (85%, mixture of four stereoisomers); Rf value: 0.27 (silica gel; dichloromethane/methanol/ammonia=9:1:0.1); C27H26Cl2N6O2 (537.45); mass spectrum: (M−H)−=535/537/539 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-7cdac9e514de4d5ba637353ea9b97cf7 |
| Source note | uspto-grants-2008_02 |