HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 178464808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178464831 | HCID 178464831 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178464808 | HCID 178464808 | 31% |
Reaction Steps
Prepared analogously to Example 1g from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and S-prolinamide in tetrahydrofuran. Yield: 31%; Rf value: 0.15 (silica gel; dichloromethane/ethanol=9:1); C22H21Cl2N5O3 (474.35); mass spectrum: (M+H)+=474/476/478 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-857ae5d5774644be9793f951375b7c08 |
| Source note | uspto-grants-2008_02 |