HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178453652, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 178504636 | HCID 178504636 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178453652 | HCID 178453652 | 46% |
Reaction Steps
Prepared analogously to Example 85 from N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfinylpropyl]-3-chloro-4-[(2S)-2-(N-tert-butoxycarbonylaminomethyl)pyrrolidin-1-ylcarbonyl]benzamide and 2 equivalents of 3-chloroperoxybenzoic acid in dichloromethane/glacial acetic acid. Yield: 46%; Rf value: 0.38 (silica gel; dichloromethane/methanol=9:1); C29H35Cl2N5O6S (652.60); mass spectrum: (M+H)+=652/654/656 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a686660a4d9e4cf6bb5052dd095de5e9 |
| Source note | uspto-grants-2008_02 |